Highest-grossing film by a female director at the domestic box office (opening weekend)

- Who
- Greta Gerwig, Barbie
- What
- 162,022,044 US dollar(s)
- Where
- United States
- When
- 21 July 2023
The highest-grossing film by a female director at the domestic box office (opening weekend) is $162,022,044 (£125,620,065 / €144,924,344), and was achieved by Barbie (2023), directed by Greta Gerwig (USA), released on 21 July 2023.
The previous highest grossing film with a solo female director was Wonder Woman (2017), directed by Patty Jenkins, which grossed $103,251,471 at the domestic box office in its opening weekend.