Most home runs in a Major League Baseball career by a catcher

- Who
- Mike Piazza
- Where
- Not Applicable
- When
- 2007
The Major League Baseball (MLB) record for most career home runs hit by a catcher is 427 by Mike Piazza (USA) playing for the Los Angeles Dodgers, Florida Marlins, New York Mets, San Diego Padres and Oakland Athletics (all USA) from 1992 to 2007.