Most players hitting a home run in an MLB game, both teams combined

- Who
- San Diego Padres, San Francisco Giants, New York Mets, Philadelphia Phillies, Arizona Diamondbacks
- What
- 10 people
- Where
- Mexico (Mexico City)
- When
- 29 April 2023
When the San Diego Padres defeated the San Francisco Giants (both USA) 16-11 on 29 April 2023, 10 different players (five from each team) hit home runs. As a result of this, they equalled the record set by the New York Mets and Philadelphia Phillies on 24 August 2015, and the Phillies and Arizona Diamondbacks (all USA) on 10 June 2019.
The 10 Padres and Giants players include Nelson Cruz (Dominican Republic), Juan Soto (Dominican Republic), Manny Machado (USA), Fernando Tatis Jr. (Dominican Republic), Xander Bogaerts (Aruba), Brandon Crawford (USA), LaMonte Wade Jr (USA), Mitch Haniger (USA), Blake Sabol (USA) and David Villar (USA).