Most strikeouts in an MLB postseason game (both teams)
- Who
- Houston Astros, Seattle Mariners
- What
- 42 total number
- Where
- Not Applicable
- When
- 15 October 2022
The Houston Astros and Seattle Mariners (both USA) combined for a postseason record 42 strikeouts (22 by Astros pitchers, 20 by Mariners pitchers) during Game Three of their American League Division Series, won 1–0 by the Astros in 18 innings, on 15 October 2022.