Most singles tennis matches won at the US Open
- Who
- Serena Williams
- What
- 108 total number
- Where
- United States
- When
- 01 September 2022
The most singles tennis matches won at the US Open is 108, and was achieved by Serena Williams (USA), as of 1 September 2022.
Williams' final victory came in the second round of the 2022 US Open, after which she announced her retirement from tennis.